Endocrine Abstracts

Introduction: Maternal distress, including poorer life satisfaction, increased anxiety and depression (A&D) symptoms, are worse in Severely Obese (SO) than lean pregnancy and may alter placental genes regulating foetal glucocorticoid exposure and placental growth. We hypothesised that the associations between increased maternal distress with changes in placental mRNA levels leading to a reduced placental barrier to maternal glucocorticoids, and altered placental IGF2, are ...